the Lung cancer and arsenic

Lung and arsenci

Abstract

INTRODUCTION: This review arises from the first cytogenetic study, carried out in Marcos Juárez
(Córdoba Province, Argentina), where the population had been drinking water containing more than 0.13
mg/l (0.13 ppm) of arsenic. In this work he called the attention to the relationship between lung cancer and
the arsenic content in drinking water consumption, because the causes of death of this population between
the years 1970-1988, showed a significant increase in lung cancer, this finding is similar to much research
on the subject. The literature reviewed shows that exposure to arsenic exerts deleterious effects on health
mainly through the induction of oxidative stress, alterations in DNA methylation, histone modification and
miRNA expression and it would be interesting to determine the presence and consequence of these
alterations in the populations affected by arsenic contamination of water without lose sight of other
environmental agents. Understand how it acts and the promotion of carcinogenesis related to arsenic
biotransformation processes would be important for detection and treatment in affected people.